1. His irresponsibility led to the failure of the project.
他的不负责任导致了该项目的失败。

2. The company fired him due to his repeated acts of irresponsibility.
由于他多次表现出不负责任的行为，该公司解雇了他。

3. The government's irresponsibility towards environmental issues is a major concern for the public.
政府在环境问题上的不负责任让公众非常担忧。